Lily Tomlin

Ms. Frizzle (voice)

Max Beckford

Tim (voice)

Daniel DeSanto

Carlos (voice)

Stuart Stone

Ralphie (voice)

Amos Crawley

Arnold (voice)

Erica Luttrell

Keesha (voice)

Lisa Yamanaka

Wanda (voice)

Tara Meyer

Dorothy Ann (voice)

Maia Filar

Phoebe (voice)

Malcolm-Jamal Warner

The Producer (voice)